Margaretha worked as a day laborer, collected and sold herbs and made and sold crafts. She, as a young woman, was very aware of the many poor people in her surroundings. The needs of the people in Wiedtal, particularly the needs of the orphans and the sick, were a major concern for her. Motivated by her strong faith in God, she felt called to serve the poor, sick and helpless.
In the autumn of 1851, her family now able to support themselves, Margaretha and her sister Marianne, who suffered from epilepsy, moved into the empty small quarters of the Cross Chapel in Waldbreitbach. Here they lived meagerly trusting God for their daily sustenance while carrying out the call to serve the poor and sick of the community. In addition she took in orphans, kept her work as a day laborer and taught home economics in a number of surrounding schools.